m6A
N6-methyladenosine

作为真核细胞中最普遍的RNA修饰,N6-甲基腺苷(m6ARNA甲基化积极参与了RNA代谢的调控。越来越多的证据显示,m6A与其他表观遗传修饰之间发生了复杂的相互关系,共同调控体内多种生理过程。

m6A相关课题国自然资助情况
Funding of m6A
铁死亡课题整体方案
Experiments of Ferroptosis
MeRIP-seq筛选差异基因
总m6A修饰检测
mRNA稳定性检测
RIP验证mRNA与m6A相关蛋白的结合
参考文献
References
Xiang JF, Yang Q, Liu CX, Wu M, Chen LL, Yang L. N6-Methyladenosines Modulate A-to-I RNA Editing. Mol Cell. 2018 Jan 4;69(1):126-135.e6. doi: 10.1016/j.molcel.2017.12.006. PMID: 29304330.
Zhang C, Chen L, Liu Y, Huang J, Liu A, Xu Y, Shen Y, He H, Xu D. Downregulated METTL14 accumulates BPTF that reinforces super-enhancers and distal lung metastasis via glycolytic reprogramming in renal cell carcinoma. Theranostics. 2021 Jan 26;11(8):3676-3693. doi: 10.7150/thno.55424. PMID: 33664855; PMCID: PMC7914369.
Chen C, Yuan W, Zhou Q, Shao B, Guo Y, Wang W, Yang S, Guo Y, Zhao L, Dang Q, Yang X, Wang G, Kang Q, Ji Z, Liu J, Sun Z. N6-methyladenosine-induced circ1662 promotes metastasis of colorectal cancer by accelerating YAP1 nuclear localization. Theranostics. 2021 Feb 25;11(9):4298-4315. doi: 10.7150/thno.51342. PMID: 33754062; PMCID: PMC7977475.
Zhao Y, Chen Y, Jin M, Wang J. The crosstalk between m6A RNAmethylation and other epigenetic regulators: a novel perspective in epigenetic remodeling. Theranostics. 2021 Mar 4;11(9):4549-4566. doi: 10.7150/thno.54967. PMID: 33754077; PMCID: PMC7977459.